Abstract Search

ea0034p164 | Growth and development | SFEBES2014

Distinct gene expression is associated with epigenetic and growth-related network modules in relation to gender differences in the timing of the pubertal growth spurt

De Leonibus Chiara , Chatelain Pierre , Clayton Peter , Stevens Adam

Background: The return to active long bone growth in puberty is a distinctly human event1 and occurs ~2 years earlier in girls compared to boys. Evolutionarily conserved networks of genes are associated with the developmental phases of childhood in multiple tissues2, implying the existence of a genetic program that controls the pubertal return to growth.Objectives: To identify biological functions associated with gender and age-rela...

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ea0033p67 | (1) | BSPED2013

Effect of latitude, summer daylight exposure and genetic background on growth response to recombinant human GH in GH deficient patients

De Leonibus Chiara , Chatelain Pierre , Clayton Peter , Stevens Adam

Introduction: Growth rate tends to be greater in children living at higher latitudes although the underlying mechanisms are unclear. The aim of this study was to compare height velocity (HV) in response to recombinant human GH (r-hGH) therapy in children with GH deficiency (GHD) living at different latitudes.Design: Pre-pubertal children with GHD (n=118) were enrolled from the PREDICT long-term follow-up prospective study (NCT00699855). Data wer...

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ea0036oc3.7 | Oral Communications 3 | BSPED2014

Patterns of gene expression in pre-pubertal children are associated with the severity of their GH deficiency

Stevens Adam , De Leonibus Chiara , Chatelain Pierre , Murray Philip , Clayton Peter

Background: GH deficiency (GHD) has a spectrum of severity as characterised by GH stimulation tests; the cut-off level for GHD has been a long standing contentious issue. An independent biological correlate of severity would be valuable.Objectives: To identify patterns of gene expression (GE) that correlate with severity in GHD.Methods: Pre-pubertal children with GHD (n=72) were enrolled from the PREDICT study (NCT00256126...

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Endocrine Abstracts

Distinct gene expression is associated with epigenetic and growth-related network modules in relation to gender differences in the timing of the pubertal growth spurt

Effect of latitude, summer daylight exposure and genetic background on growth response to recombinant human GH in GH deficient patients

Patterns of gene expression in pre-pubertal children are associated with the severity of their GH deficiency

BiosciAbstracts